منابع مشابه
The probability of indicating Osteoprotegrin as a biomarker for osteoporosis in patient with thalassemia major
Background: Osteoporosis is one of the main causes of morbidity in patients with thalassemia major. Osteoprotegerin (OPG) is secreted by osteoblasts and osteogenic stromal stem cells and protects the skeleton from excessive bone reabsorption. In this study, the authors aimed to assess the relationship between OPG with osteoporosis and osteopenia in patients with thalassemia major. Materials an...
متن کاملEvaluation of relationship between biochemical parameters and osteoporosis in patients with β-thalassemia major
Background: Osteoporosis is one of the late complications of β-Thalassemia major. The pathogenesis of osteoporosis depends on different factors. Ineffectiveness of hematopoiesis is the major factor, and the other factors are defected by hormonal functions or biochemical parameters. Osteoclasts hyperactivity in thalassemia increases the serum receptor activator of nuclear factor Kappa B ligand (...
متن کاملEffect of Pamidronate on Osteoporosis in Patients with β-Thalassemia Major
Background: β-thalassemia major is a hereditary life threatening anemia which requires regular blood transfusion. Clinical symptoms of the disease are growth retardation, pallor, jaundice and skeletal alternations. The variety of bone disease in thalassemia major is manifested by diffuse bone pain or deformity, spontaneous and pathologic fractures and osteopenia or osteoporosis. This study aime...
متن کاملIron overload causes osteoporosis in Thalassemia Major patients through interaction with TRPV1 channels
The pathogenesis of bone resorption in β-Thalassemia Major is multifactorial and our understanding of the underlying molecular and cellular mechanisms remains incomplete. Considering the emerging importance of the endocannabinoid/endovanilloid system in bone metabolism, examining a potential role for this system in the development of osteoporosis in β-Thalassemia Major and its relationship with...
متن کاملThe cutoff of ferritin for evaluation of osteoporosis in patients with Thalassemia Major: A cross-sectional analytic study
Background: This study aimed to assess cutoff of ferritin for evaluation of osteoporosis in patients with Thalassemia Major (TM). Materials and Methods: This analytic cross-sectional study was conducted in17 Shahrivar children's hospital, Rasht, Iran, from November 2017 to November 2018. The inclusion criteria were indicated as the presence of TM in patients aged 12-19 years old with records ...
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ژورنال
عنوان ژورنال: Türk Osteoporoz Dergisi
سال: 2012
ISSN: 2146-3816
DOI: 10.4274/tod.02411